Publication: Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial
Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial
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Frey, M., Smigielski, L., Tini, E., Fekete, S., Fleischhaker, C., Wewetzer, C., Karwautz, A., Correll, C. U., Gerlach, M., Taurines, R., Plener, P. L., Malzahn, U., Kornbichler, S., Weninger, L., Brockhaus, M., Reuter-Dang, S.-Y., Reitzle, K., Rock, H., Imgart, H., … Egberts, K. M. (2023). Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial. Pharmaceutics, 15(9), 2202. https://doi.org/10.3390/pharmaceutics15092202
Abstract
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Abstract
Fluoxetine is the recommended first-line antidepressant in many therapeutic guidelines for children and adolescents. However, little is known about the relationships between drug dose and serum level as well as the therapeutic serum reference range in this age group. Within a large naturalistic observational prospective multicenter clinical trial (“TDM-VIGIL”), a transdiagnostic sample of children and adolescents (n = 138; mean age, 15; range, 7–18 years; 24.6% males) was treated with fluoxetine (10–40 mg/day). Analyses of both the la
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- Frey, Michael
- Smigielski, Lukasz
- Tini, Elvira
- Fekete, Stefanie
- Fleischhaker, Christian
- Wewetzer, Christoph
- Karwautz, Andreas
- Correll, Christoph U
- Gerlach, Manfred
- Taurines, Regina
- Plener, Paul L
- Malzahn, Uwe
- Kornbichler, Selina
- Weninger, Laura
- Brockhaus, Matthias
- Reuter-Dang, Su-Yin
- Reitzle, Karl
- Rock, Hans
- Imgart, Hartmut
- Heuschmann, Peter
- Unterecker, Stefan
- Briegel, Wolfgang
- Banaschewski, Tobias
- Fegert, Jörg M
- Hellenschmidt, Tobias
- Kaess, Michael
- Kölch, Michael
- Renner, Tobias
- Rexroth, Christian
- Walitza, Susanne
- Schulte-Körne, Gerd
- Romanos, Marcel
- Egberts, Karin M
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Frey, M., Smigielski, L., Tini, E., Fekete, S., Fleischhaker, C., Wewetzer, C., Karwautz, A., Correll, C. U., Gerlach, M., Taurines, R., Plener, P. L., Malzahn, U., Kornbichler, S., Weninger, L., Brockhaus, M., Reuter-Dang, S.-Y., Reitzle, K., Rock, H., Imgart, H., … Egberts, K. M. (2023). Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial. Pharmaceutics, 15(9), 2202. https://doi.org/10.3390/pharmaceutics15092202
