Publication: Proteomic and genomic analysis of acid dentin lysate with focus on TGF-β signaling
Proteomic and genomic analysis of acid dentin lysate with focus on TGF-β signaling
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Nasirzade, J., Kargarpour, Z., Mitulović, G., Strauss, F. J., Panahipour, L., Schwarz, F., & Gruber, R. (2021). Proteomic and genomic analysis of acid dentin lysate with focus on TGF-β signaling. Scientific Reports, 11, 12247. https://doi.org/10.1038/s41598-021-89996-6
Abstract
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Abstract
Particulate autologous tooth roots are increasingly used for alveolar bone augmentation; however, the proteomic profile of acid dentin lysate and the respective cellular response have not been investigated. Here we show that TGF-β1 is among the 226 proteins of acid dentin lysate (ADL) prepared from porcine teeth. RNA sequencing identified 231 strongly regulated genes when gingival fibroblasts were exposed to ADL. Out of these genes, about one third required activation of the TGF-β receptor type I kinase including interleukin 11 (IL11)
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Creators (Authors)
- Nasirzade, Jila
- Kargarpour, Zahra
- Mitulović, Goran
- Strauss, Franz Josef
- Panahipour, Layla
- Schwarz, Frank
- Gruber, Reinhard
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Citations
Nasirzade, J., Kargarpour, Z., Mitulović, G., Strauss, F. J., Panahipour, L., Schwarz, F., & Gruber, R. (2021). Proteomic and genomic analysis of acid dentin lysate with focus on TGF-β signaling. Scientific Reports, 11, 12247. https://doi.org/10.1038/s41598-021-89996-6
