Publication: Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts
Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts
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Mynarek, M., Obrecht, D., Sill, M., Sturm, D., Kloth-Stachnau, K., Selt, F., Ecker, J., von Hoff, K., Juhnke, B.-O., Goschzik, T., Pietsch, T., Bockmayr, M., Kool, M., von Deimling, A., Witt, O., Schüller, U., Benesch, M., Gerber, N. U., Sahm, F., … Milde, T. (2023). Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts. Acta Neuropathologica, 145, 97–112. https://doi.org/10.1007/s00401-022-02522-4
Abstract
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Abstract
Molecular groups of medulloblastoma (MB) are well established. Novel risk stratification parameters include Group 3/4 (non-WNT/non-SHH) methylation subgroups I-VIII or whole-chromosomal aberration (WCA) phenotypes. This study investigates the integration of clinical and molecular parameters to improve risk stratification of non-WNT/non-SHH MB. Non-WNT/non-SHH MB from the HIT2000 study and the HIT-MED registries were selected based on availability of DNA-methylation profiling data. MYC or MYCN amplification and WCA of chromosomes 7, 8,
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- Mynarek, Martin
- Obrecht, Denise
- Sill, Martin
- Sturm, Dominik
- Kloth-Stachnau, Katja
- Selt, Florian
- Ecker, Jonas
- von Hoff, Katja
- Juhnke, Björn-Ole
- Goschzik, Tobias
- Pietsch, Torsten
- Bockmayr, Michael
- Kool, Marcel
- von Deimling, Andreas
- Witt, Olaf
- Schüller, Ulrich
- Benesch, Martin
- Gerber, Nicolas U
- Sahm, Felix
- Jones, David T W
- Korshunov, Andrey
- Pfister, Stefan M
- Rutkowski, Stefan
- Milde, Till
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Mynarek, M., Obrecht, D., Sill, M., Sturm, D., Kloth-Stachnau, K., Selt, F., Ecker, J., von Hoff, K., Juhnke, B.-O., Goschzik, T., Pietsch, T., Bockmayr, M., Kool, M., von Deimling, A., Witt, O., Schüller, U., Benesch, M., Gerber, N. U., Sahm, F., … Milde, T. (2023). Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts. Acta Neuropathologica, 145, 97–112. https://doi.org/10.1007/s00401-022-02522-4
