Publication: The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis
The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis
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Seidenberg, J., Stellato, M., Hukara, A., Ludewig, B., Klingel, K., Distler, O., Błyszczuk, P., & Kania, G. (2021). The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis. International Journal of Molecular Sciences, 22(4), 1861. https://doi.org/10.3390/ijms22041861
Abstract
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BACKGROUND: Pathological activation of cardiac fibroblasts is a key step in development and progression of cardiac fibrosis and heart failure. This process has been associated with enhanced autophagocytosis, but molecular mechanisms remain largely unknown.
METHODS AND RESULTS: Immunohistochemical analysis of endomyocardial biopsies showed increased activation of autophagy in fibrotic hearts of patients with inflammatory cardiomyopathy. In vitro experiments using mouse and human cardiac fibroblasts confirmed that blockade of autophagy
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Creators (Authors)
- Seidenberg, Jemima
- Stellato, Mara
- Hukara, Amela
- Ludewig, Burkhard
- Klingel, Karin
- Distler, Oliver
- Błyszczuk, Przemysław
- Kania, Gabriela
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Citations
Seidenberg, J., Stellato, M., Hukara, A., Ludewig, B., Klingel, K., Distler, O., Błyszczuk, P., & Kania, G. (2021). The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis. International Journal of Molecular Sciences, 22(4), 1861. https://doi.org/10.3390/ijms22041861
