Publication: Use of Levosimendan in Intensive Care Unit Settings: An Opinion Paper
Use of Levosimendan in Intensive Care Unit Settings: An Opinion Paper
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Herpain, A., Bouchez, S., Girardis, M., Guarracino, F., Knotzer, J., Levy, B., Liebregts, T., Pollesello, P., Ricksten, S.-E., Riha, H., Rudiger, A., & Sangalli, F. (2019). Use of Levosimendan in Intensive Care Unit Settings: An Opinion Paper. Journal of Cardiovascular Pharmacology, 73(1), 3–14. https://doi.org/10.1097/fjc.0000000000000636
Abstract
Abstract
Abstract
Levosimendan is an inodilator that promotes cardiac contractility primarily via calcium sensitization of cardiac troponin C and vasodilatation via opening of adenosine triphosphate-sensitive potassium (KATP) channels in vascular smooth muscle cells; the drug also exerts organ-protective effects via a similar effect on mitochondrial KATP channels.
This pharmacological profile identifies levosimendan as a drug that may have applications in a wide range of critical illness situations encountered in intensive care unit medicine: hemodyna
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Creators (Authors)
- Herpain, A
- Bouchez, S
- Girardis, M
- Guarracino, F
- Knotzer, J
- Levy, B
- Liebregts, T
- Pollesello, P
- Ricksten, S-E
- Riha, H
- Rudiger, A
- Sangalli, F
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Citations
Herpain, A., Bouchez, S., Girardis, M., Guarracino, F., Knotzer, J., Levy, B., Liebregts, T., Pollesello, P., Ricksten, S.-E., Riha, H., Rudiger, A., & Sangalli, F. (2019). Use of Levosimendan in Intensive Care Unit Settings: An Opinion Paper. Journal of Cardiovascular Pharmacology, 73(1), 3–14. https://doi.org/10.1097/fjc.0000000000000636
