Publication: Delayed tumor-draining lymph node irradiation preserves the efficacy of combined radiotherapy and immune checkpoint blockade in models of metastatic disease
Delayed tumor-draining lymph node irradiation preserves the efficacy of combined radiotherapy and immune checkpoint blockade in models of metastatic disease
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Telarovic, I., Yong, C. S. M., Kurz, L., Vetrugno, I., Reichl, S., Fernandez, A. S., Cheng, H.-W., Winkler, R., Guckenberger, M., Kipar, A., Ludewig, B., & Pruschy, M. (2024). Delayed tumor-draining lymph node irradiation preserves the efficacy of combined radiotherapy and immune checkpoint blockade in models of metastatic disease. Nature Communications, 15, 5500. https://doi.org/10.1038/s41467-024-49873-y
Abstract
Abstract
Abstract
Cancer resistance to immune checkpoint inhibitors motivated investigations into leveraging the immunostimulatory properties of radiotherapy to overcome immune evasion and to improve treatment response. However, clinical benefits of radiotherapy-immunotherapy combinations have been modest. Routine concomitant tumor-draining lymph node irradiation (DLN IR) might be the culprit. As crucial sites for generating anti-tumor immunity, DLNs are indispensable for the in situ vaccination effect of radiotherapy. Simultaneously, DLN sparing is of
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- Yong, Carmen S M
- Kurz, Lisa
- Vetrugno, Irene
- Reichl, Sabrina
- Fernandez, Alba Sanchez
- Cheng, Hung-Wei
- Winkler, Rona
- Guckenberger, Matthias
- Kipar, Anja
- Ludewig, Burkhard
- Pruschy, Martin
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Telarovic, I., Yong, C. S. M., Kurz, L., Vetrugno, I., Reichl, S., Fernandez, A. S., Cheng, H.-W., Winkler, R., Guckenberger, M., Kipar, A., Ludewig, B., & Pruschy, M. (2024). Delayed tumor-draining lymph node irradiation preserves the efficacy of combined radiotherapy and immune checkpoint blockade in models of metastatic disease. Nature Communications, 15, 5500. https://doi.org/10.1038/s41467-024-49873-y
