Publication: Cellular and molecular effects of the liposomal mTHPC derivative Foslipos in prostate carcinoma cells in-vitro
Cellular and molecular effects of the liposomal mTHPC derivative Foslipos in prostate carcinoma cells in-vitro
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Besic Gyenge, E., Hiestand, S., Graefe, S., Walt, H., & Maake, C. (2011). Cellular and molecular effects of the liposomal mTHPC derivative Foslipos in prostate carcinoma cells in-vitro. Photodiagnosis and Photodynamic Therapy, 8, 86–96. https://doi.org/10.1016/j.pdpdt.2011.02.001
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BACKGROUND: Meso-tetra-hydroxyphenyl-chlorine (mTHPC) is among the most powerful photosensitizers available for photodynamic therapy (PDT). However, the mechanisms leading to cell death are poorly understood. We here focused on changes at DNA and RNA levels after treatment with the liposomal mTHPC derivative Foslipos in vitro. METHODS: After determination of darktoxicity, laser conditions and uptake kinetics, PC-3 prostate carcinoma cells were subjected to PDT with Foslipos, followed by assessment of cell numbers directly (TP0) or 1h
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- Besic Gyenge, E
- Hiestand, S
- Graefe, S
- Walt, H
- Maake, C
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Besic Gyenge, E., Hiestand, S., Graefe, S., Walt, H., & Maake, C. (2011). Cellular and molecular effects of the liposomal mTHPC derivative Foslipos in prostate carcinoma cells in-vitro. Photodiagnosis and Photodynamic Therapy, 8, 86–96. https://doi.org/10.1016/j.pdpdt.2011.02.001
