Publication: Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis
Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis
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Angelini, G., Panunzi, S., Castagneto-Gissey, L., Pellicanò, F., De Gaetano, A., Pompili, M., Riccardi, L., Garcovich, M., Raffaelli, M., Ciccoritti, L., Verrastro, O., Russo, M. F., Vecchio, F. M., Casella, G., Casella-Mariolo, J., Papa, L., Marini, P. L., Rubino, F., le Roux, C. W., … Mingrone, G. (2023). Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis. Gut, 72(2), 392–403. https://doi.org/10.1136/gutjnl-2022-327498
Abstract
Abstract
Abstract
OBJECTIVE
Clinical diagnosis and approval of new medications for non-alcoholic steatohepatitis (NASH) require invasive liver biopsies. The aim of our study was to identify non-invasive biomarkers of NASH and/or liver fibrosis.
DESIGN
This multicentre study includes 250 patients (discovery cohort, n=100 subjects (Bariatric Surgery Versus Non-alcoholic Steato-hepatitis - BRAVES trial); validation cohort, n=150 (Liquid Biopsy for NASH and Liver Fibrosis - LIBRA trial)) with histologically proven non-alcoholic fatty liver (NAFL) or NAS
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Creators (Authors)
- Angelini, Giulia
- Panunzi, Simona
- Castagneto-Gissey, Lidia
- Pellicanò, Francesca
- De Gaetano, Andrea
- Pompili, Maurizio
- Riccardi, Laura
- Garcovich, Matteo
- Raffaelli, Marco
- Ciccoritti, Luigi
- Verrastro, Ornella
- Russo, Maria Francesca
- Vecchio, Fabio Maria
- Casella, Giovanni
- Casella-Mariolo, James
- Papa, Luigi
- Marini, Pier Luigi
- Rubino, Francesco
- le Roux, Carel W
- Bornstein, Stefan
- Mingrone, Geltrude
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Angelini, G., Panunzi, S., Castagneto-Gissey, L., Pellicanò, F., De Gaetano, A., Pompili, M., Riccardi, L., Garcovich, M., Raffaelli, M., Ciccoritti, L., Verrastro, O., Russo, M. F., Vecchio, F. M., Casella, G., Casella-Mariolo, J., Papa, L., Marini, P. L., Rubino, F., le Roux, C. W., … Mingrone, G. (2023). Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis. Gut, 72(2), 392–403. https://doi.org/10.1136/gutjnl-2022-327498
