Publication: A Metabolic Landscape for Maintaining Retina Integrity and Function
A Metabolic Landscape for Maintaining Retina Integrity and Function
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Viegas, F. O., & Neuhauss, S. C. F. (2021). A Metabolic Landscape for Maintaining Retina Integrity and Function. Frontiers in Molecular Neuroscience, 14, 656000. https://doi.org/10.3389/fnmol.2021.656000
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Neurons have high metabolic demands that are almost exclusively met by glucose supplied from the bloodstream. Glucose is utilized in complex metabolic interactions between neurons and glia cells, described by the astrocyte-neuron lactate shuttle (ANLS) hypothesis. The neural retina faces similar energy demands to the rest of the brain, with additional high anabolic needs to support continuous renewal of photoreceptor outer segments. This demand is met by a fascinating variation of the ANLS in which photoreceptors are the central part
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Viegas, F. O., & Neuhauss, S. C. F. (2021). A Metabolic Landscape for Maintaining Retina Integrity and Function. Frontiers in Molecular Neuroscience, 14, 656000. https://doi.org/10.3389/fnmol.2021.656000