Publication: miR-181a/b control the assembly of visual circuitry by regulating retinal axon specification and growth
miR-181a/b control the assembly of visual circuitry by regulating retinal axon specification and growth
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Carrella, S., D’Agostino, Y., Barbato, S., Huber-Reggi, S. P., Salierno, F. G., Manfredi, A., Neuhauss, S. C. F., Banfi, S., & Conte, I. (2015). miR-181a/b control the assembly of visual circuitry by regulating retinal axon specification and growth. Developmental Neurobiology, 75, 1252–1267. https://doi.org/10.1002/dneu.22282
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Abstract
Connectivity and function of neuronal circuitry require the correct specification and growth of axons and dendrites. Here, we identify the microRNAs miR-181a and miR-181b as key regulators of retinal axon specification and growth. Loss of miR-181a/b in medaka fish (Oryzias latipes) failed to consolidate amacrine cell processes into axons and delayed the growth of retinal ganglion cell (RGC) axons. These alterations were accompanied by defects in visual connectivity and function. We demonstrated that miR-181a/b exert these actions thro
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- Carrella, Sabrina
- D'Agostino, Ylenia
- Barbato, Sara
- Huber-Reggi, Sabina P
- Salierno, Francesco G
- Manfredi, Anna
- Banfi, Sandro
- Conte, Ivan
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Carrella, S., D’Agostino, Y., Barbato, S., Huber-Reggi, S. P., Salierno, F. G., Manfredi, A., Neuhauss, S. C. F., Banfi, S., & Conte, I. (2015). miR-181a/b control the assembly of visual circuitry by regulating retinal axon specification and growth. Developmental Neurobiology, 75, 1252–1267. https://doi.org/10.1002/dneu.22282