Publication: Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro
Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro
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Fuchs, D., Rohrer Bley, C., Morandi, L., Tonon, C., Weyland, M. S., & Nytko, K. J. (2023). Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro. Veterinary Medicine and Science, 9(4), 1573–1583. https://doi.org/10.1002/vms3.1181
Abstract
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BackgroundCombined chemoradiation offers a promising therapeutic strategy for dogs with glioma. The alkylating agents temozolomide (TMZ) and lomustine (CCNU) penetrate the blood‐brain barrier, and doses for dogs are established. Whether such combinations are clinically advantageous remains to be explored together with tumour‐specific markers.ObjectiveTo investigate if triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro.MethodsWe evaluated the sensitising effect of CCNU alone and i
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Creators (Authors)
- Fuchs, Daniel
- Morandi, Luca
- Tonon, Caterina
- Weyland, Mathias S
- Nytko, Katarzyna J
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Citations
Fuchs, D., Rohrer Bley, C., Morandi, L., Tonon, C., Weyland, M. S., & Nytko, K. J. (2023). Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro. Veterinary Medicine and Science, 9(4), 1573–1583. https://doi.org/10.1002/vms3.1181
