Publication: Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
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Domingo, E., Freeman-Mills, L., Rayner, E., et al, & Koelzer, V. H. (2016). Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study. Lancet Gastroenterology & Hepatology, 1(3), 207–216. https://doi.org/10.1016/S2468-1253(16)30014-0
Abstract
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BACKGROUND: Precision cancer medicine depends on defining distinct tumour subgroups using biomarkers that may occur at very modest frequencies. One such subgroup comprises patients with exceptionally mutated (ultramutated) cancers caused by mutations that impair DNA polymerase epsilon (POLE) proofreading. METHODS: We examined the association of POLE proofreading domain mutation with clinicopathological variables and immune response in colorectal cancers from clinical trials (VICTOR, QUASAR2, and PETACC-3) and colorectal cancer cohorts
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- Domingo, Enric
- Freeman-Mills, Luke
- Rayner, Emily
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Domingo, E., Freeman-Mills, L., Rayner, E., et al, & Koelzer, V. H. (2016). Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study. Lancet Gastroenterology & Hepatology, 1(3), 207–216. https://doi.org/10.1016/S2468-1253(16)30014-0