Publication: Dynamics and Plasticity of Stem Cells in the Regenerating Human Colonic Epithelium
Dynamics and Plasticity of Stem Cells in the Regenerating Human Colonic Epithelium
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Kahnwald, M. (2024). Dynamics and Plasticity of Stem Cells in the Regenerating Human Colonic Epithelium. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-260412
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The human intestinal epithelium is a tissue with rapid turnover. Its complex regenerative process and differentiation trajectories have been challenging to study due to its inaccessibility and lack of temporal sampling. To this end, we developed a workflow to culture adult stem cell-derived human intestinal organoids from single cells to maturation. Extensive characterization of our model system indicated a transient regenerative response, followed by differentiation into all mature cell lineages. This switch is accompanied by a trans
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Kahnwald, M. (2024). Dynamics and Plasticity of Stem Cells in the Regenerating Human Colonic Epithelium. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-260412
