Publication: Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation
Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation
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Hopp, A.-K., Teloni, F., Bisceglie, L., Gondrand, C., Raith, F., Nowak, K., Muskalla, L., Howald, A., Pedrioli, P. G. A., Johnsson, K., Altmeyer, M., Pedrioli, D. M. L., & Hottiger, M. O. (2021). Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation. Molecular Cell, 81(2), 340-354.e5. https://doi.org/10.1016/j.molcel.2020.12.034
Abstract
Abstract
Abstract
In addition to its role as an electron transporter, mitochondrial nicotinamide adenine dinucleotide (NAD+) is an important co-factor for enzymatic reactions, including ADP-ribosylation. Although mitochondria harbor the most intra-cellular NAD+, mitochondrial ADP-ribosylation remains poorly understood. Here we provide evidence for mitochondrial ADP-ribosylation, which was identified using various methodologies including immunofluorescence, western blot, and mass spectrometry. We show that mitochondrial ADP-ribosylation reversibly incre
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- Hopp, Ann-Katrin
- Teloni, Federico
- Bisceglie, Lavinia
- Gondrand, Corentin
- Raith, Fabio
- Nowak, Kathrin
- Muskalla, Lukas
- Howald, Anna
- Pedrioli, Patrick G A
- Johnsson, Kai
- Altmeyer, Matthias
- Pedrioli, Deena M Leslie
- Hottiger, Michael O
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European Research Council
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Hopp, A.-K., Teloni, F., Bisceglie, L., Gondrand, C., Raith, F., Nowak, K., Muskalla, L., Howald, A., Pedrioli, P. G. A., Johnsson, K., Altmeyer, M., Pedrioli, D. M. L., & Hottiger, M. O. (2021). Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation. Molecular Cell, 81(2), 340-354.e5. https://doi.org/10.1016/j.molcel.2020.12.034
