Publication: Generation of a mono-ubiquitinated PCNA mimic by click chemistry
Generation of a mono-ubiquitinated PCNA mimic by click chemistry
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Eger, S., Castrec, B., Hübscher, U., Scheffner, M., Rubini, M., & Marx, A. (2011). Generation of a mono-ubiquitinated PCNA mimic by click chemistry. Chembiochem, 12(18), 2807–2812. https://doi.org/10.1002/cbic.201100444
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Abstract
Genotoxic stress results in more than 50 000 damaged DNA sites per cell per day. During DNA replication, processive high-fidelity DNA polymerases generally stall at DNA lesions and have to be displaced by translesion synthesis DNA polymerases, which are able to bypass the lesion. This switch is mediated by mono-ubiquitination of the processivity factor proliferating cell nuclear antigen (PCNA). To further investigate the regulation of the DNA polymerase exchange, we developed an easy and efficient method to synthesize site-specificall
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- Eger, S
- Castrec, B
- Hübscher, U
- Scheffner, M
- Rubini, M
- Marx, A
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Eger, S., Castrec, B., Hübscher, U., Scheffner, M., Rubini, M., & Marx, A. (2011). Generation of a mono-ubiquitinated PCNA mimic by click chemistry. Chembiochem, 12(18), 2807–2812. https://doi.org/10.1002/cbic.201100444