Publication: Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation
Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation
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Patsenker, E., Sachse, P., Chicca, A., Gachet, M. S., Schneider, V., Mattsson, J., Lanz, C., Worni, M., de Gottardi, A., Semmo, M., Hampe, J., Schafmayer, C., Brenneisen, R., Gertsch, J., Stickel, F., & Semmo, N. (2015). Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. International Journal of Molecular Sciences, 16(4), 7057–7076. https://doi.org/10.3390/ijms16047057
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Abstract
The endocannabinoid (EC) system is implicated in many chronic liver diseases, including hepatitis C viral (HCV) infection. Cannabis consumption is associated with fibrosis progression in patients with chronic hepatitis C (CHC), however, the role of ECs in the development of CHC has never been explored. To study this question, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) were quantified in samples of HCV patients and healthy controls by gas and liquid chromatography mass spectrometry. Fatty acid amide hydrolase (FAAH) and monoac
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- Patsenker, Eleonora
- Sachse, Philip
- Chicca, Andrea
- Gachet, María Salomé
- Schneider, Vreni
- Mattsson, Johan
- Lanz, Christian
- Worni, Mathias
- de Gottardi, Andrea
- Semmo, Mariam
- Hampe, Jochen
- Schafmayer, Clemens
- Brenneisen, Rudolf
- Gertsch, Jürg
- Stickel, Felix
- Semmo, Nasser
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Patsenker, E., Sachse, P., Chicca, A., Gachet, M. S., Schneider, V., Mattsson, J., Lanz, C., Worni, M., de Gottardi, A., Semmo, M., Hampe, J., Schafmayer, C., Brenneisen, R., Gertsch, J., Stickel, F., & Semmo, N. (2015). Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. International Journal of Molecular Sciences, 16(4), 7057–7076. https://doi.org/10.3390/ijms16047057
