Publication: Potent Inducers of Paraptosis through Electronic Tuning of Hemicyanine Electrophiles
Potent Inducers of Paraptosis through Electronic Tuning of Hemicyanine Electrophiles
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Tamez-Fernández, J. F., Steven, C., Nguyen, J., & Rivera Fuentes, P. (2025). Potent Inducers of Paraptosis through Electronic Tuning of Hemicyanine Electrophiles. Journal of the American Chemical Society, 147(36), 32571–32579. https://doi.org/10.1021/jacs.5c07109
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Paraptosis is a distinct form of programmed cell death characterized by cytoplasmic vacuolization, mitochondrial swelling, and endoplasmic reticulum (ER) dilation, offering an alternative to apoptosis for therapeutic applications. In this study, we identified a hemicyanine derivative that is a potent paraptosis inducer in two cancer cell lines. This compound triggers hallmark paraptotic features, including ER swelling, mitochondrial morphological changes, increased superoxide production, and caspase-independent cell death. This activi
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Tamez-Fernández, J. F., Steven, C., Nguyen, J., & Rivera Fuentes, P. (2025). Potent Inducers of Paraptosis through Electronic Tuning of Hemicyanine Electrophiles. Journal of the American Chemical Society, 147(36), 32571–32579. https://doi.org/10.1021/jacs.5c07109
