Publication: The Role of Intervertebral Disc Cartilage Catabolites in Modic Type 1 Changes
The Role of Intervertebral Disc Cartilage Catabolites in Modic Type 1 Changes
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Mengis, T. (2024). The Role of Intervertebral Disc Cartilage Catabolites in Modic Type 1 Changes. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-260411
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The thesis investigates the pathobiology of Modic changes (MCs), specifically focusing on Modic type 1 changes (MC1), emphasizing the complexity of the disease. Although MCs manifest as vertebral bone marrow lesions, the inflammation and degeneration observed in the neighboring intervertebral disc and cartilage endplate (CEP) are also closely linked to MCs. However, the underlying mechanisms and how the tissues crosstalk to induce MC development are unclear to this point. Yet, comprehending these pathobiological mechanisms is crucial
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Publications of Department of Molecular Mechanisms of Disease
Publications of Department of Molecular Mechanisms of Disease
Publications of Institute of Molecular Life Sciences
Publications of Institute of Physiology
Publications of Institute of Physiology
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Mengis, T. (2024). The Role of Intervertebral Disc Cartilage Catabolites in Modic Type 1 Changes. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-260411
