Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

Zurkirchen, Luis; Varum, Sandra; Giger, Sonja; Klug, Annika; Häusel, Jessica; Bossart, Raphaël; Zemke, Martina; Cantù, Claudio; Atak, Zeynep Kalender; Zamboni, Nicola; Basler, Konrad; Sommer, Lukas

doi:10.5167/uzh-171189

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Zurkirchen, L., Varum, S., Giger, S., Klug, A., Häusel, J., Bossart, R., Zemke, M., Cantù, C., Atak, Z. K., Zamboni, N., Basler, K., & Sommer, L. (2019). Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nature Communications, 10, 2192. https://doi.org/10.1038/s41467-019-09823-5

Abstract

The transcription factor Yin Yang 1 (YY1) plays an important role in human disease. It is often overexpressed in cancers and mutations can lead to a congenital haploinsufficiency syndrome characterized by craniofacial dysmorphisms and neurological dysfunctions, consistent with a role in brain development. Here, we show that Yy1 controls murine cerebral cortex development in a stage-dependent manner. By regulating a wide range of metabolic pathways and protein translation, Yy1 maintains proliferation and survival of neural progenitor c