Publication: Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex
Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex
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Grossen, C., Keller, L. F., Biebach, I., The International Goat Genome Consortium, & Croll, D. (2014). Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex. PLoS Genetics, 10, e1004438. https://doi.org/10.1371/journal.pgen.1004438
Abstract
Abstract
Abstract
The major histocompatibility complex (MHC) is a crucial component of the vertebrate immune system and shows extremely high levels of genetic polymorphism. The extraordinary genetic variation is thought to be ancient polymorphisms maintained by balancing selection. However, introgression from related species was recently proposed as an additional mechanism. Here we provide evidence for introgression at the MHC in Alpine ibex (Capra ibex ibex). At a usually very polymorphic MHC exon involved in pathogen recognition (DRBexon 2), Alpine i
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- Grossen, Christine
- Biebach, Iris
- Croll, Daniel
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Citations
Grossen, C., Keller, L. F., Biebach, I., The International Goat Genome Consortium, & Croll, D. (2014). Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex. PLoS Genetics, 10, e1004438. https://doi.org/10.1371/journal.pgen.1004438
