Publication: Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
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Duffet, L., Williams, E. T., Gresch, A., Chen, S., Bhat, M. A., Benke, D., Hartrampf, N., & Patriarchi, T. (2023). Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution. ELife, 12, RP86628. https://doi.org/10.7554/elife.86628.3
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The glucagon-like peptide-1 receptor (GLP1R) is a broadly expressed target of peptide hormones with essential roles in energy and glucose homeostasis, as well as of the blockbuster weight-loss drugs semaglutide and liraglutide. Despite its large clinical relevance, tools to investigate the precise activation dynamics of this receptor with high spatiotemporal resolution are limited. Here, we introduce a novel genetically encoded sensor based on the engineering of a circularly permuted green fluorescent protein into the human GLP1R, nam
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Duffet, L., Williams, E. T., Gresch, A., Chen, S., Bhat, M. A., Benke, D., Hartrampf, N., & Patriarchi, T. (2023). Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution. ELife, 12, RP86628. https://doi.org/10.7554/elife.86628.3
