Publication: Challenging Tumor Heterogeneity with HER2, p16 and Somatostatin Receptor 2 Expression in a Case of EBV-Associated Lymphoepithelial Carcinoma of the Salivary Gland
Challenging Tumor Heterogeneity with HER2, p16 and Somatostatin Receptor 2 Expression in a Case of EBV-Associated Lymphoepithelial Carcinoma of the Salivary Gland
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Adili, A., O’Connor, T., Wales, P., Seemann, M., Höller, S., Hummer, B., Freiberger, S. N., Rauthe, S., & Rupp, N. J. (2023). Challenging Tumor Heterogeneity with HER2, p16 and Somatostatin Receptor 2 Expression in a Case of EBV-Associated Lymphoepithelial Carcinoma of the Salivary Gland. Head and Neck Pathology, 17(4), 1052–1057. https://doi.org/10.1007/s12105-023-01592-4
Abstract
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BACKGROUND
Lymphoepithelial carcinoma of the salivary glands (LECSG) is a rare disease in the Western hemisphere that is typically associated with an EBV infection. The molecular mechanisms of LECSG tumorigenesis are poorly understood.
RESULTS
Here we report a case of EBV-associated LECSG with an unusual immunophenotype. The tumor exhibited bi-morphic histological features with a mutually exclusive expression of HER2 and p16. The p16-positive domain of the tumor immunohistochemically co-expressed late membrane protein 1 (LMP-1), wh
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- Adili, Arlind
- O'Connor, Tracy
- Wales, Philipp
- Seemann, Marcus
- Höller, Sylvia
- Hummer, Barbara
- Freiberger, Sandra N
- Rauthe, Stephan
- Rupp, Niels J
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Adili, A., O’Connor, T., Wales, P., Seemann, M., Höller, S., Hummer, B., Freiberger, S. N., Rauthe, S., & Rupp, N. J. (2023). Challenging Tumor Heterogeneity with HER2, p16 and Somatostatin Receptor 2 Expression in a Case of EBV-Associated Lymphoepithelial Carcinoma of the Salivary Gland. Head and Neck Pathology, 17(4), 1052–1057. https://doi.org/10.1007/s12105-023-01592-4
