Publication: Deletion of the Coffin–Lowry Syndrome Gene Rsk2 in Mice is Associated With Impaired Spatial Learning and Reduced Control of Exploratory Behavior
Deletion of the Coffin–Lowry Syndrome Gene Rsk2 in Mice is Associated With Impaired Spatial Learning and Reduced Control of Exploratory Behavior
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Poirier, R., Jacquot, S., Vaillend, C., Soutthiphong, A. A., Libbey, M., Davis, S., Laroche, S., Hanauer, A., Welzl, H., Lipp, H.-P., & Wolfer, D. P. (2007). Deletion of the Coffin–Lowry Syndrome Gene Rsk2 in Mice is Associated With Impaired Spatial Learning and Reduced Control of Exploratory Behavior. Behavior Genetics, 37(1), 31–50. https://doi.org/10.1007/s10519-006-9116-1
Abstract
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Abstract
Coffin-Lowry Syndrome (CLS) is an X-linked syndromic form of mental retardation associated with skeletal abnormalities. It is caused by mutations of the Rsk2 gene, which encodes a growth factor regulated kinase. Gene deletion studies in mice have shown an essential role for the Rsk2 gene in osteoblast differentiation and function, establishing a causal link between Rsk2 deficiency and skeletal abnormalities of CLS. Although analyses in mice have revealed prominent expression of Rsk2 in brain structures that are essential for learning
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- Poirier, R
- Jacquot, S
- Vaillend, C
- Soutthiphong, A A
- Libbey, M
- Davis, S
- Laroche, S
- Hanauer, A
- Welzl, H
- Lipp, H-P
- Wolfer, D P
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Poirier, R., Jacquot, S., Vaillend, C., Soutthiphong, A. A., Libbey, M., Davis, S., Laroche, S., Hanauer, A., Welzl, H., Lipp, H.-P., & Wolfer, D. P. (2007). Deletion of the Coffin–Lowry Syndrome Gene Rsk2 in Mice is Associated With Impaired Spatial Learning and Reduced Control of Exploratory Behavior. Behavior Genetics, 37(1), 31–50. https://doi.org/10.1007/s10519-006-9116-1
