Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial

Robba, Chiara; Nielsen, Niklas; Dankiewicz, Josef; et al; Wendel-Garcia, Pedro David

doi:10.1136/bmjopen-2021-058001

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Robba, C., Nielsen, N., Dankiewicz, J., et al, & Wendel-Garcia, P. D. (2022). Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial. BMJ Open, 12(3), e058001. https://doi.org/10.1136/bmjopen-2021-058001

Abstract

IntroductionMechanical ventilation is a fundamental component in the management of patients post cardiac arrest. However, the ventilator settings and the gas-exchange targets used after cardiac arrest may not be optimal to minimise post-anoxic secondary brain injury. Therefore, questions remain regarding the best ventilator management in such patients.Methods and analysisThis is a preplanned analysis of the international randomised controlled trial, targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest