Publication: The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1
The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1
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Reuther, C., Heinzle, V., Nölting, S., Herterich, S., Hahner, S., Halilovic, E., Jeay, S., Wuerthner, J. U., Aristizabal Prada, E. T., Spöttl, G., Maurer, J., & Auernhammer, C. J. (2018). The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology, 106(1), 1–19. https://doi.org/10.1159/000453369
Abstract
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Abstract
BACKGROUND/AIMS
The tumor suppressor p53 is depleted in many tumor cells by the E3 ubiquitin ligase mouse double minute 2 homolog (MDM2) through MDM2/p53 interaction. A novel target for inhibiting p53 degradation and for causing reexpression of p53wild type is inhibition of MDM2. The small molecule NVP-CGM097 is a novel MDM2 inhibitor. We investigated MDM2 inhibition as a target in neuroendocrine tumor cells in vitro.
METHODS
Human neuroendocrine tumor cell lines from the pancreas (BON1), lung (NCI-H727), and midgut (GOT1) were inc
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Creators (Authors)
- Reuther, Clemens
- Heinzle, Vera
- Nölting, Svenja
- Herterich, Sabine
- Hahner, Stefanie
- Halilovic, Ensar
- Jeay, Sébastien
- Wuerthner, Jens U
- Aristizabal Prada, Elke Tatjana
- Spöttl, Gerald
- Maurer, Julian
- Auernhammer, Christoph J
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Reuther, C., Heinzle, V., Nölting, S., Herterich, S., Hahner, S., Halilovic, E., Jeay, S., Wuerthner, J. U., Aristizabal Prada, E. T., Spöttl, G., Maurer, J., & Auernhammer, C. J. (2018). The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology, 106(1), 1–19. https://doi.org/10.1159/000453369
