Reduced sleep spindle density in adolescent patients with early-onset schizophrenia compared to major depressive disorder and healthy controls

Gerstenberg, Miriam; Furrer, Melanie; Tesler, Noemi; Franscini, Maurizia; Walitza, Susanne; Huber, Reto

doi:10.5167/uzh-181636

Citations

Citation copied

Gerstenberg, M., Furrer, M., Tesler, N., Franscini, M., Walitza, S., & Huber, R. (2020). Reduced sleep spindle density in adolescent patients with early-onset schizophrenia compared to major depressive disorder and healthy controls. Schizophrenia Research, 221, 20–28. https://doi.org/10.1016/j.schres.2019.11.060

Abstract

OBJECTIVES: During adolescence schizophrenia and major depressive disorder (MDD) increasingly emerge. Overlapping symptomatology during first presentation challenges the diagnostic process. Reduced sleep spindle density (SSD) was suggested as a biomarker in adults, discerning patients with schizophrenia from patients with depression or healthy controls (HC). We aimed to compare SSD in early-onset schizophrenia (EOS), with MDD, and HC, and to analyse associations of SSD with symptomatology and neurocognitive measures. METHODS: Automati