Publication: Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat
Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat
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van Landeghem, F. K., Stover, J. F., Bechmann, I., Brück, W., Unterberg, A., Bührer, C., & von Deimling, A. (2001). Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia, 35, 167–179. https://doi.org/10.1002/glia.1082
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Abstract
Traumatic brain injury is followed by increased extracellular glutamate concentration. Uptake of glutamate is mainly mediated by the glial glutamate transporters GLAST and GLT-1. Extent and distribution of GLAST and GLT-1 were studied in a rat model of controlled cortical impact injury (CCII). Western Blot analysis revealed lowest levels of GLAST and GLT-1 with a decrease by 40%-54% and 42%-49% between 24 and 72 h posttrauma. By 8 h after CCII, CSF glutamate levels were increased (10.5 microM vs. 2.56 microM in controls; P < 0.001), r
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- Stover, J F
- Bechmann, I
- Unterberg, A
- von Deimling, A
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van Landeghem, F. K., Stover, J. F., Bechmann, I., Brück, W., Unterberg, A., Bührer, C., & von Deimling, A. (2001). Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia, 35, 167–179. https://doi.org/10.1002/glia.1082
