Publication: Guidance on the use of the threshold of toxicological concern approach in food safety assessment
Guidance on the use of the threshold of toxicological concern approach in food safety assessment
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More, S. J., Bampidis, V., Benford, D., Bragard, C., Halldorsson, T. I., Hernández‐Jerez, A. F., Hougaard Bennekou, S., Koutsoumanis, K. P., Machera, K., Naegeli, H., Nielsen, S. S., Schlatter, J. R., Schrenk, D., Silano, V., Turck, D., Younes, M., Gundert‐Remy, U., Kass, G. E. N., Kleiner, J., … Wallace, H. M. (2019). Guidance on the use of the threshold of toxicological concern approach in food safety assessment. EFSA Journal, 17(6), e05708. https://doi.org/10.2903/j.efsa.2019.5708
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The Scientific Committee confirms that the Threshold of Toxicological Concern (TTC) is a pragmatic screening and prioritisation tool for use in food safety assessment. This Guidance provides clear step‐by‐step instructions for use of the TTC approach. The inclusion and exclusion criteria are defined and the use of the TTC decision tree is explained. The approach can be used when the chemical structure of the substance is known, there are limited chemical‐specific toxicity data and the exposure can be estimated. The TTC approach should
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More, S. J., Bampidis, V., Benford, D., Bragard, C., Halldorsson, T. I., Hernández‐Jerez, A. F., Hougaard Bennekou, S., Koutsoumanis, K. P., Machera, K., Naegeli, H., Nielsen, S. S., Schlatter, J. R., Schrenk, D., Silano, V., Turck, D., Younes, M., Gundert‐Remy, U., Kass, G. E. N., Kleiner, J., … Wallace, H. M. (2019). Guidance on the use of the threshold of toxicological concern approach in food safety assessment. EFSA Journal, 17(6), e05708. https://doi.org/10.2903/j.efsa.2019.5708
