Linker histones are fine-scale chromatin architects modulating developmental decisions in Arabidopsis

Rutowicz, Kinga; Lirski, Maciej; Mermaz, Benoît; Teano, Gianluca; Schubert, Jasmin; Mestiri, Imen; Kroteń, Magdalena A; Fabrice, Tohnyui Ndinyanka; Fritz, Simon; Grob, Stefan; Ringli, Christoph; Cherkezyan, Lusik; Barneche, Fredy; Jerzmanowski, Andrzej; Baroux, Célia

doi:10.1186/s13059-019-1767-3

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Rutowicz, K., Lirski, M., Mermaz, B., Teano, G., Schubert, J., Mestiri, I., Kroteń, M. A., Fabrice, T. N., Fritz, S., Grob, S., Ringli, C., Cherkezyan, L., Barneche, F., Jerzmanowski, A., & Baroux, C. (2019). Linker histones are fine-scale chromatin architects modulating developmental decisions in Arabidopsis. Genome Biology, 20, 157. https://doi.org/10.1186/s13059-019-1767-3

Abstract

BACKGROUND:

Chromatin provides a tunable platform for gene expression control. Besides the well-studied core nucleosome, H1 linker histones are abundant chromatin components with intrinsic potential to influence chromatin function. Well studied in animals, little is known about the evolution of H1 function in other eukaryotic lineages for instance plants. Notably, in the model plant Arabidopsis, while H1 is known to influence heterochromatin and DNA methylation, its contribution to transcription, molecular, and cytological chromatin