Publication: ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice
ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice
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Srimat Kandadai, K., Kotur, M. B., Dokalis, N., Amrein, I., Keller, C. W., Münz, C., Wolfer, D., Prinz, M., & Lünemann, J. D. (2021). ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice. Autophagy, 17(11), 3566–3576. https://doi.org/10.1080/15548627.2021.1883880
Abstract
Abstract
Abstract
Microglia, resident myeloid immune cells of the central nervous system (CNS), actively shape the circuitry of the brain, maintain CNS homeostasis during the steady state and orchestrate immune responses upon CNS injury. Both canonical and non-canonical functions of the macroautophagy/autophagy-related protein ATG5 regulate myeloid cell survival and immune responses. Here, we report that loss of ATG5 in postnatal microglia does not perturb CNS tissue integrity, microglial cell survival, or immune activation. Learning task performances
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- Srimat Kandadai, Keertana
- Kotur, Monika B
- Dokalis, Nikolaos
- Amrein, Irmgard
- Keller, Christian W
- Münz, Christian
- Wolfer, David
- Prinz, Marco
- Lünemann, Jan D
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Srimat Kandadai, K., Kotur, M. B., Dokalis, N., Amrein, I., Keller, C. W., Münz, C., Wolfer, D., Prinz, M., & Lünemann, J. D. (2021). ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice. Autophagy, 17(11), 3566–3576. https://doi.org/10.1080/15548627.2021.1883880
