Publication: The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism
The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism
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Ruiz-Serrano, A., Boyle, C. N., Monné Rodríguez, J. M., Günter, J., Jucht, A. E., Pfundstein, S., Bapst, A. M., Lutz, T. A., Wenger, R. H., & Scholz, C. C. (2022). The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism. International Journal of Molecular Sciences, 23, 1536. https://doi.org/10.3390/ijms23031536
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Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic homeostasis is of utmost importance for the identification of therapeutic targets for the treatment of metabolically driven diseases. We previously identified the deubiquitinase OTUB1 as substrate for the cellular oxygen sensor factor-inhibiting HIF (FIH) with regulatory effects on cellular energy metabolism, but the physiological relevance of OTUB1 is unclear. Here, we report t
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- Ruiz-Serrano, Amalia
- Boyle, Christina N
- Monné Rodríguez, Josep M
- Jucht, Agnieszka E
- Pfundstein, Svende
- Bapst, Andreas M
- Wenger, Roland H
- Scholz, Carsten C
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Ruiz-Serrano, A., Boyle, C. N., Monné Rodríguez, J. M., Günter, J., Jucht, A. E., Pfundstein, S., Bapst, A. M., Lutz, T. A., Wenger, R. H., & Scholz, C. C. (2022). The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism. International Journal of Molecular Sciences, 23, 1536. https://doi.org/10.3390/ijms23031536
