Publication: CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms
CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms
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Brunner, E., Yagi, R., Debrunner, M., Beck-Schneider, D., Burger, A., Escher, E., Mosimann, C., Hausmann, G., & Basler, K. (2019). CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms. Life Science Alliance, 2, e201800267. https://doi.org/10.26508/lsa.201800267
Abstract
Abstract
Abstract
CRISPR–Cas9–based genome editing has transformed the life sciences, enabling virtually unlimited genetic manipulation of genomes: The RNA-guided Cas9 endonuclease cuts DNA at a specific target sequence and the resulting double-strand breaks are mended by one of the intrinsic cellular repair pathways. Imprecise double-strand repair will introduce random mutations such as indels or point mutations, whereas precise editing will restore or specifically edit the locus as mandated by an endogenous or exogenously provided template. Recent st
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- Brunner, Erich
- Yagi, Ryohei
- Debrunner, Marc
- Beck-Schneider, Dezirae
- Burger, Alexa
- Escher, Eliane
- Mosimann, Christian
- Hausmann, George
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Brunner, E., Yagi, R., Debrunner, M., Beck-Schneider, D., Burger, A., Escher, E., Mosimann, C., Hausmann, G., & Basler, K. (2019). CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms. Life Science Alliance, 2, e201800267. https://doi.org/10.26508/lsa.201800267
