Publication: Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis
Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis
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Ospelt, C., Bang, H., Feist, E., Camici, G., Keller, S., Detert, J., Krämer, A., Gay, S., Ghannam, K., & Burmester, G. R. (2017). Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis. Annals of the Rheumatic Diseases, 76(7), 1176–1183. https://doi.org/10.1136/annrheumdis-2016-210059
Abstract
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Abstract
OBJECTIVES: Smoking has been connected to citrullination of antigens and formation of anti-citrullinated peptide antibodies (ACPAs) in rheumatoid arthritis (RA). Since smoking can modify proteins by carbamylation (formation of homocitrulline), this study was conducted to investigate these effects on vimentin in animal models and RA. METHODS: The efficiency of enzymatic carbamylation of vimentin was characterised. B-cell response was investigated after immunisation of rabbits with different vimentin isoforms. Effects of tobacco smoke e
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- Ospelt, Caroline
- Bang, Holger
- Feist, Eugen
- Camici, Giovanni
- Keller, Stephan
- Detert, Jacqueline
- Krämer, Anette
- Gay, Steffen
- Ghannam, Khetam
- Burmester, Gerd R
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Ospelt, C., Bang, H., Feist, E., Camici, G., Keller, S., Detert, J., Krämer, A., Gay, S., Ghannam, K., & Burmester, G. R. (2017). Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis. Annals of the Rheumatic Diseases, 76(7), 1176–1183. https://doi.org/10.1136/annrheumdis-2016-210059
