Publication: The L cell transcriptome is unaffected by vertical sleeve gastrectomy but highly dependent upon position within the gastrointestinal tract
The L cell transcriptome is unaffected by vertical sleeve gastrectomy but highly dependent upon position within the gastrointestinal tract
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Rollins, K. A., Opitz, L., Arnold, M., Simon, E., Neubauer, H., & Wolfrum, S. (2019). The L cell transcriptome is unaffected by vertical sleeve gastrectomy but highly dependent upon position within the gastrointestinal tract. Peptides, 113, 22–34. https://doi.org/10.1016/j.peptides.2019.01.001
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Abstract
Altered GLP-1 secretion from L cells has been implicated in the development of type 2 diabetes mellitus and its resolution following bariatric surgery. However, changes in L cell gene expression, which may form the basis for altered functionality after high fat diet (HFD) or bariatric surgery, have either not been investigated or have given conflicting results. We developed a gcg-DTR-eGFP reporter mouse to isolate ileal and colonic L cells from HFD fed insulin resistant mice and mice showing improved glucose tolerance following vertic
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- Rollins, Katherine A
- Opitz, Lennart
- Arnold, Myrtha
- Simon, Eric
- Neubauer, Heike
- Wolfrum, Susanne
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Rollins, K. A., Opitz, L., Arnold, M., Simon, E., Neubauer, H., & Wolfrum, S. (2019). The L cell transcriptome is unaffected by vertical sleeve gastrectomy but highly dependent upon position within the gastrointestinal tract. Peptides, 113, 22–34. https://doi.org/10.1016/j.peptides.2019.01.001
