Publication: Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells
Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells
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Citations
Yakimovich, A., Witte, R., Andriasyan, V., Georgi, F., & Greber, U. F. (2018). Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells. MSphere, 3(6), e00599-18. https://doi.org/10.1128/mSphereDirect.00599-18
Abstract
Abstract
Abstract
Cytopathic effects (CPEs) are a hallmark of infections. CPEs are difficult to observe due to phototoxicity from classical light microscopy. We report distinct patterns of virus infections in live cells using digital holo-tomographic microscopy (DHTM). DHTM is label-free and records the phase shift of low-energy light passing through the specimen on a transparent surface with minimal perturbation. DHTM measures the refractive index (RI) and computes the refractive index gradient (RIG), unveiling optical heterogeneity in cells. We find
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Creators (Authors)
- Yakimovich, Artur
- Witte, Robert
- Andriasyan, Vardan
- Georgi, Fanny
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Citations
Yakimovich, A., Witte, R., Andriasyan, V., Georgi, F., & Greber, U. F. (2018). Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells. MSphere, 3(6), e00599-18. https://doi.org/10.1128/mSphereDirect.00599-18
