Publication: DNA methylation networks underlying mammalian traits
DNA methylation networks underlying mammalian traits
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Haghani, A., Li, C. Z., Robeck, T. R., Zhang, J., Lu, A. T., Ablaeva, J., Acosta-Rodríguez, V. A., Adams, D. M., Alagaili, A. N., Almunia, J., Aloysius, A., Amor, N. M. S., Ardehali, R., Arneson, A., Baker, C. S., Banks, G., Belov, K., Bennett, N. C., Black, P., … Krützen, M. (2023). DNA methylation networks underlying mammalian traits. Science, 381(6658), eabq5693. https://doi.org/10.1126/science.abq5693
Abstract
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Abstract
Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency t
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Creators (Authors)
- Haghani, Amin
- Li, Caesar Z
- Robeck, Todd R
- Zhang, Joshua
- Lu, Ake T
- Ablaeva, Julia
- Acosta-Rodríguez, Victoria A
- Adams, Danielle M
- Alagaili, Abdulaziz N
- Almunia, Javier
- Aloysius, Ajoy
- Amor, Nabil M S
- Ardehali, Reza
- Arneson, Adriana
- Baker, C Scott
- Banks, Gareth
- Belov, Katherine
- Bennett, Nigel C
- Black, Peter
- Blumstein, Daniel T
- Bors, Eleanor K
- Breeze, Charles E
- Brooke, Robert T
- Brown, Janine L
- Carter, Gerald
- Caulton, Alex
- Cavin, Julie M
- Chakrabarti, Lisa
- Chatzistamou, Ioulia
- Chavez, Andreas S
- Krützen, Michael
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Haghani, A., Li, C. Z., Robeck, T. R., Zhang, J., Lu, A. T., Ablaeva, J., Acosta-Rodríguez, V. A., Adams, D. M., Alagaili, A. N., Almunia, J., Aloysius, A., Amor, N. M. S., Ardehali, R., Arneson, A., Baker, C. S., Banks, G., Belov, K., Bennett, N. C., Black, P., … Krützen, M. (2023). DNA methylation networks underlying mammalian traits. Science, 381(6658), eabq5693. https://doi.org/10.1126/science.abq5693
