Publication: NPC1 links cholesterol trafficking to microglial morphology via the gastrosome
NPC1 links cholesterol trafficking to microglial morphology via the gastrosome
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Zareba, J., Cattaneo, E. F., Villani, A., Othman, A., Streb, S., & Peri, F. (2024). NPC1 links cholesterol trafficking to microglial morphology via the gastrosome. Nature Communications, 15(1), 8638. https://doi.org/10.1038/s41467-024-52874-6
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Microglia play important roles in brain development and homeostasis by removing dying neurons through efferocytosis. Morphological changes in microglia are hallmarks of many neurodegenerative conditions, such as Niemann-Pick disease type C. Here, NPC1 loss causes microglia to shift from a branched to an ameboid form, though the cellular basis and functional impact of this change remain unclear. Using zebrafish, we show that NPC1 deficiency causes an efferocytosis-dependent expansion of the microglial gastrosome, a collection point for
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Zareba, J., Cattaneo, E. F., Villani, A., Othman, A., Streb, S., & Peri, F. (2024). NPC1 links cholesterol trafficking to microglial morphology via the gastrosome. Nature Communications, 15(1), 8638. https://doi.org/10.1038/s41467-024-52874-6
