Publication: Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome
Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome
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Vaheri, A., Smura, T., Vauhkonen, H., Hepojoki, J., Sironen, T., Strandin, T., Tietäväinen, J., Outinen, T., Mäkelä, S., Pörsti, I., & Mustonen, J. (2023). Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome. Viruses, 15, 805. https://doi.org/10.3390/v15030805
Abstract
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Abstract
The clinical outcome of Puumala hantavirus (PUUV) infection shows extensive variation, ranging from inapparent subclinical infection (70–80%) to severe hemorrhagic fever with renal syndrome (HFRS), with about 0.1% of cases being fatal. Most hospitalized patients experience acute kidney injury (AKI), histologically known as acute hemorrhagic tubulointerstitial nephritis. Why this variation? There is no evidence that there would be more virulent and less virulent variants infecting humans, although this has not been extensively studied.
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- Vaheri, Antti
- Smura, Teemu
- Vauhkonen, Hanna
- Hepojoki, Jussi
- Sironen, Tarja
- Strandin, Tomas
- Tietäväinen, Johanna
- Outinen, Tuula
- Mäkelä, Satu
- Pörsti, Ilkka
- Mustonen, Jukka
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Vaheri, A., Smura, T., Vauhkonen, H., Hepojoki, J., Sironen, T., Strandin, T., Tietäväinen, J., Outinen, T., Mäkelä, S., Pörsti, I., & Mustonen, J. (2023). Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome. Viruses, 15, 805. https://doi.org/10.3390/v15030805
