Publication: Adipose-derived Stromal Cell Therapy Combined with a Short Course Non-Myeloablative Conditioning Promotes Long-term Graft Tolerance in Vascularized Composite Allotransplantation
Adipose-derived Stromal Cell Therapy Combined with a Short Course Non-Myeloablative Conditioning Promotes Long-term Graft Tolerance in Vascularized Composite Allotransplantation
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Schweizer, R., Taddeo, A., Waldner, M., Klein, H. J., Fuchs, N., Kamat, P., Targosinski, S., Barth, A. A., Drach, M. C., Gorantla, V. S., Cinelli, P., & Plock, J. A. (2020). Adipose-derived Stromal Cell Therapy Combined with a Short Course Non-Myeloablative Conditioning Promotes Long-term Graft Tolerance in Vascularized Composite Allotransplantation. American Journal of Transplantation, 20(5), 1272–1284. https://doi.org/10.1111/ajt.15726
Abstract
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Abstract
The risks of chronic immunosuppression limit the utility of vascularized composite allotransplantation (VCA) as reconstructive option in complex tissue defects. We evaluated a novel, clinically translatable, radiation-free conditioning protocol that combines anti-lymphocyte serum (ALS), tacrolimus and CTLA4-Ig with adipose-derived stromal cells (ASCs) to allow VCA survival without long-term systemic immunosuppression. Full-mismatched rat hind-limb transplant recipients received tacrolimus (0.5mg/kg) for 14 days and were assigned to fo
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Creators (Authors)
- Schweizer, Riccardo
- Taddeo, Adriano
- Waldner, Matthias
- Klein, Holger J
- Fuchs, Nina
- Kamat, Pranitha
- Targosinski, Stefan
- Barth, André A
- Drach, Mathias C
- Gorantla, Vijay S
- Cinelli, Paolo
- Plock, Jan A
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Schweizer, R., Taddeo, A., Waldner, M., Klein, H. J., Fuchs, N., Kamat, P., Targosinski, S., Barth, A. A., Drach, M. C., Gorantla, V. S., Cinelli, P., & Plock, J. A. (2020). Adipose-derived Stromal Cell Therapy Combined with a Short Course Non-Myeloablative Conditioning Promotes Long-term Graft Tolerance in Vascularized Composite Allotransplantation. American Journal of Transplantation, 20(5), 1272–1284. https://doi.org/10.1111/ajt.15726
