T2 MRI visible Perivascular Spaces in Parkinson`s Disease: clinical significance and association with polysomnography measured sleep

Meinhold, Lena; Gennari, Antonio G; Baumann-Vogel, Heide; Werth, Esther; Schreiner, Simon J; Ineichen, Christian; Baumann, Christian R; O'Gorman Tuura, Ruth

doi:10.5167/uzh-264584

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Meinhold, L., Gennari, A. G., Baumann-Vogel, H., Werth, E., Schreiner, S. J., Ineichen, C., Baumann, C. R., & O’Gorman Tuura, R. (2025). T2 MRI visible Perivascular Spaces in Parkinson`s Disease: clinical significance and association with polysomnography measured sleep. Sleep, 48, zsae233. https://doi.org/10.1093/sleep/zsae233

Abstract

Poor sleep quality might contribute to the risk and progression of neurodegenerative disorders via deficient cerebral waste clearance functions during sleep. In this retrospective cross-sectional study, we explore the link between enlarged perivascular spaces (PVS), a putative marker of sleep-dependent glymphatic clearance, with sleep quality and motor symptoms in Parkinson`s disease (PD) patients. T2-weighted MRI images of 20 patients and 17 healthy control subjects were estimated visually for PVS in the basal ganglia (BG) and centru