Publication: Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects
Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects
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Kannan, A., Suomalainen, M., Volle, R., Bauer, M., Amsler, M., Trinh, H. V., Vavassori, S., Pachlopnik Schmid, J., Vilhena, G., Marin-Gonzalez, A., Pérez, R., Franceschini, A., von Mering, C., Hemmi, S., & Greber, U. F. (2022). Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects. Viruses, 14(7), 1407. https://doi.org/10.3390/v14071407
Abstract
Abstract
Abstract
Pathogen-associated molecular patterns, including cytoplasmic DNA and double-strand (ds)RNA trigger the induction of interferon (IFN) and antiviral states protecting cells and organisms from pathogens. Here we discovered that the transfection of human airway cell lines or non-transformed fibroblasts with 24mer dsRNA mimicking the cellular micro-RNA (miR)29b-1* gives strong anti-viral effects against human adenovirus type 5 (AdV-C5), influenza A virus X31 (H3N2), and SARS-CoV-2. These anti-viral effects required blunt-end complementary
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Creators (Authors)
- Kannan, Abhilash
- Suomalainen, Maarit
- Volle, Romain
- Bauer, Michael
- Amsler, Marco
- Trinh, Hung V
- Vavassori, Stefano
- Vilhena, Guilherme
- Marin-Gonzalez, Alberto
- Pérez, Rubén
- Franceschini, Andrea
- Hemmi, Silvio
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Citations
Kannan, A., Suomalainen, M., Volle, R., Bauer, M., Amsler, M., Trinh, H. V., Vavassori, S., Pachlopnik Schmid, J., Vilhena, G., Marin-Gonzalez, A., Pérez, R., Franceschini, A., von Mering, C., Hemmi, S., & Greber, U. F. (2022). Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects. Viruses, 14(7), 1407. https://doi.org/10.3390/v14071407
