Investigating the Cytotoxicity of Ru(II) Polypyridyl Complexes by Changing the Electronic Structure of Salicylaldehyde Ligands

Taghizadeh Shool, Maryam; Amiri Rudbari, Hadi; Cuevas-Vicario, José V; Rodríguez-Rubio, Andrea; Stagno, Claudio; Iraci, Nunzio; Efferth, Thomas; Omer, Ejlal A; Schirmeister, Tanja; Blacque, Olivier; Moini, Nakisa; Sheibani, Esmail; Micale, Nicola

doi:10.1021/acs.inorgchem.3c03414

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Taghizadeh Shool, M., Amiri Rudbari, H., Cuevas-Vicario, J. V., Rodríguez-Rubio, A., Stagno, C., Iraci, N., Efferth, T., Omer, E. A., Schirmeister, T., Blacque, O., Moini, N., Sheibani, E., & Micale, N. (2024). Investigating the Cytotoxicity of Ru(II) Polypyridyl Complexes by Changing the Electronic Structure of Salicylaldehyde Ligands. Inorganic Chemistry, 63(2), 1083–1101. https://doi.org/10.1021/acs.inorgchem.3c03414

Abstract

A novel class of Ru(II)-based polypyridyl complexes with an auxiliary salicylaldehyde ligand [Ru(phen)2(X-Sal)]BF4 {X: H (1), 5-Cl (2), 5-Br (3), 3,5-Cl2 (4), 3,5-Br2 (5), 3-Br,5-Cl (6), 3,5-I2 (7), 5-NO2 (8), 5-Me (9), 4-Me (10), 4-OMe (11), and 4-DEA (12), has been synthesized and characterized by elemental analysis, FT-IR, and 1H/13C NMR spectroscopy. The molecular structure of 4, 6, 9, 10, and 11 was determined by single-crystal X-ray diffraction analysis which revealed structural similarities. DFT and TD-DFT calculations showed t