Dynamic buffering of extracellular chemokine by a dedicated scavenger pathway enables robust adaptation during directed tissue migration

Wong, Mie; Newton, Lionel R; Hartmann, Jonas; Hennrich, Marco L; Wachsmuth, Malte; Ronchi, Paolo; Guzmán-Herrera, Alejandra; Schwab, Yannick; Gavin, Anne-Claude; Gilmour, Darren

doi:10.1016/j.devcel.2020.01.013

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Wong, M., Newton, L. R., Hartmann, J., Hennrich, M. L., Wachsmuth, M., Ronchi, P., Guzmán-Herrera, A., Schwab, Y., Gavin, A.-C., & Gilmour, D. (2020). Dynamic buffering of extracellular chemokine by a dedicated scavenger pathway enables robust adaptation during directed tissue migration. Developmental Cell, 52(4), 492-508.e10. https://doi.org/10.1016/j.devcel.2020.01.013

Abstract

How tissues migrate robustly through changing guidance landscapes is poorly understood. Here, quantitative imaging is combined with inducible perturbation experiments to investigate the mechanisms that ensure robust tissue migration in vivo. We show that tissues exposed to acute "chemokine floods" halt transiently before they perfectly adapt, i.e., return to the baseline migration behavior in the continued presence of elevated chemokine levels. A chemokine-triggered phosphorylation of the atypical chemokine receptor Cxcr7b reroutes it