Publication: The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks
The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks
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Burdova, K., Mihaljevic, B., Sturzenegger, A., Chappidi, N., & Janscak, P. (2015). The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks. Molecular Cell, 59, 603–614. https://doi.org/10.1016/j.molcel.2015.06.026
Abstract
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Ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase, a master regulator of DNA-damage response, is activated by RPA-coated single-stranded DNA (ssDNA) generated at stalled replication forks or DNA double-strand breaks (DSBs). Here, we identify the mismatch-binding protein MutSβ, a heterodimer of MSH2 and MSH3, as a key player in this process. MSH2 and MSH3 form a complex with ATR and its regulatory partner ATRIP, and their depletion compromises the formation of ATRIP foci and phosphorylation of ATR substrates in cells
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- Burdova, Kamila
- Mihaljevic, Boris
- Sturzenegger, Andreas
- Chappidi, Nagaraja
- Janscak, Pavel
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Burdova, K., Mihaljevic, B., Sturzenegger, A., Chappidi, N., & Janscak, P. (2015). The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks. Molecular Cell, 59, 603–614. https://doi.org/10.1016/j.molcel.2015.06.026
