Publication: Developmental origin of patchy axonal connectivity in the neocortex: A computational model
Developmental origin of patchy axonal connectivity in the neocortex: A computational model
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Bauer, R., Zubler, F., Hauri, A., Muir, D. R., & Douglas, R. J. (2014). Developmental origin of patchy axonal connectivity in the neocortex: A computational model. Cerebral Cortex, 24(2), 487–500. https://doi.org/10.1093/cercor/bhs327
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Injections of neural tracers into many mammalian neocortical areas reveal a common patchy motif of clustered axonal projections. We studied in simulation a mathematical model for neuronal development in order to investigate how this patchy connectivity could arise in layer II/III of the neocortex. In our model, individual neurons of this layer expressed the activator–inhibitor components of a Gierer–Meinhardt reaction–diffusion system. The resultant steady-state reaction–diffusion pattern across the neuronal population was approximate
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Bauer, R., Zubler, F., Hauri, A., Muir, D. R., & Douglas, R. J. (2014). Developmental origin of patchy axonal connectivity in the neocortex: A computational model. Cerebral Cortex, 24(2), 487–500. https://doi.org/10.1093/cercor/bhs327