Soluble delta-like 1 homolog decreases in patients with acromegaly following pituitary surgery: A potential mediator of adipogenesis suppression by growth hormone?

Sze, Lisa; Tschopp, Oliver; Neidert, Marian C; Bernays, René L; Ghirlanda, Claudia; Zwimpfer, Cornelia; Wiesli, Peter; Schmid, Christoph

doi:10.1016/j.ghir.2019.02.002

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Sze, L., Tschopp, O., Neidert, M. C., Bernays, R. L., Ghirlanda, C., Zwimpfer, C., Wiesli, P., & Schmid, C. (2019). Soluble delta-like 1 homolog decreases in patients with acromegaly following pituitary surgery: A potential mediator of adipogenesis suppression by growth hormone? Growth Hormone & IGF Research, 45, 20–24. https://doi.org/10.1016/j.ghir.2019.02.002

Abstract

OBJECTIVE GH excess in acromegaly leads to lower fat mass and insulin resistance; both reverse following pituitary surgery. Soluble delta like-1 homolog (sDlk1) inhibits adipocyte differentiation and may mediate the antiadipogenic effects of GH. It is released into the circulation by ectodomain shedding through 'A Disintegrin And Metalloproteinase domain 17' (ADAM17), which also sheds soluble α-Klotho (sKlotho). Klotho is a transmembrane protein, which influences life span. sKlotho inhibits insulin signalling, and is markedly elevate