The interacting rotifer-biopolymers are anti- and disaggregating agents for human-type beta-amyloid in vitro

Datki, Zsolt; Balazs, Evelin; Galik, Bence; Sinka, Rita; Zeitler, Lavinia; Bozso, Zsolt; Kalman, Janos; Hortobagyi, Tibor; Galik-Olah, Zita

doi:10.1016/j.ijbiomac.2021.12.184

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Datki, Z., Balazs, E., Galik, B., Sinka, R., Zeitler, L., Bozso, Z., Kalman, J., Hortobagyi, T., & Galik-Olah, Z. (2022). The interacting rotifer-biopolymers are anti- and disaggregating agents for human-type beta-amyloid in vitro. International Journal of Biological Macromolecules, 201, 262–269. https://doi.org/10.1016/j.ijbiomac.2021.12.184

Abstract

Neurodegeneration-related human-type beta-amyloid 1-42 aggregates (H-Aβ) are one of the biochemical markers and executive molecules in Alzheimer's disease. The exogenic rotifer-specific biopolymer, namely Rotimer, has a protective effect against H-Aβ toxicity on Euchlanis dilatata and Lecane bulla monogonant rotifers. Due to the external particle-dependent secreting activity of these animals, this natural exudate exists in a bound form on the surface of epoxy-metal beads, named as Rotimer Inductor Conglomerate (RIC). In this current w