Publication: ChromID identifies the protein interactome at chromatin marks
ChromID identifies the protein interactome at chromatin marks
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Villaseñor, R., Pfaendler, R., Ambrosi, C., Butz, S., Giuliani, S., Bryan, E., Sheahan, T. W., Gable, A. L., Schmolka, N., Manzo, M., Wirz, J., Feller, C., von Mering, C., Aebersold, R., Voigt, P., & Baubec, T. (2020). ChromID identifies the protein interactome at chromatin marks. Nature Biotechnology, 38, 728–736. https://doi.org/10.1038/s41587-020-0434-2
Abstract
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Abstract
Chromatin modifications regulate genome function by recruiting proteins to the genome. However, the protein composition at distinct chromatin modifications has yet to be fully characterized. In this study, we used natural protein domains as modular building blocks to develop engineered chromatin readers (eCRs) selective for DNA methylation and histone tri-methylation at H3K4, H3K9 and H3K27 residues. We first demonstrated their utility as selective chromatin binders in living cells by stably expressing eCRs in mouse embryonic stem cel
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- Villaseñor, Rodrigo
- Pfaendler, Ramon
- Ambrosi, Christina
- Butz, Stefan
- Giuliani, Sara
- Bryan, Elana
- Sheahan, Thomas W
- Gable, Annika L
- Schmolka, Nina
- Manzo, Massimiliano
- Wirz, Joël
- Feller, Christian
- Aebersold, Ruedi
- Voigt, Philipp
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Villaseñor, R., Pfaendler, R., Ambrosi, C., Butz, S., Giuliani, S., Bryan, E., Sheahan, T. W., Gable, A. L., Schmolka, N., Manzo, M., Wirz, J., Feller, C., von Mering, C., Aebersold, R., Voigt, P., & Baubec, T. (2020). ChromID identifies the protein interactome at chromatin marks. Nature Biotechnology, 38, 728–736. https://doi.org/10.1038/s41587-020-0434-2
