Identifying the drivers of multidrug-resistant Klebsiella pneumoniae at a European level

Kachalov, Viacheslav N; Nguyen, Huyen; Balakrishna, Suraj; Salazar-Vizcaya, Luisa; Sommerstein, Rami; Kuster, Stefan P; Hauser, Anthony; Abel Zur Wiesch, Pia; Klein, Eili; Kouyos, Roger D

doi:10.1371/journal.pcbi.1008446

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Kachalov, V. N., Nguyen, H., Balakrishna, S., Salazar-Vizcaya, L., Sommerstein, R., Kuster, S. P., Hauser, A., Abel Zur Wiesch, P., Klein, E., & Kouyos, R. D. (2021). Identifying the drivers of multidrug-resistant Klebsiella pneumoniae at a European level. PLoS Computational Biology, 17, e1008446. https://doi.org/10.1371/journal.pcbi.1008446

Abstract

Beta-lactam- and in particular carbapenem-resistant Enterobacteriaceae represent a major public health threat. Despite strong variation of resistance across geographical settings, there is limited understanding of the underlying drivers. To assess these drivers, we developed a transmission model of cephalosporin- and carbapenem-resistant Klebsiella pneumoniae. The model is parameterized using antibiotic consumption and demographic data from eleven European countries and fitted to the resistance rates for Klebsiella pneumoniae for thes