De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer

Steiner, Sabrina; Seleznik, Gitta M; Reding, Theresia; Stopic, Matea; Lenggenhager, Daniela; ten Buren, Emiel; Eshmuminov, Dilmurodjon; Endhardt, Katharina; Hagedorn, Catherine; Heidenblut, Anna M; Bratus-Neuenschwander, Anna; Grossmann, Jonas; Trachsel, Christian; Jabbar, Karolina S; Hahn, Stephan A; vom Berg, Johannes; Graf, Rolf; Gupta, Anurag

doi:10.5167/uzh-219576

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Steiner, S., Seleznik, G. M., Reding, T., Stopic, M., Lenggenhager, D., ten Buren, E., Eshmuminov, D., Endhardt, K., Hagedorn, C., Heidenblut, A. M., Bratus-Neuenschwander, A., Grossmann, J., Trachsel, C., Jabbar, K. S., Hahn, S. A., vom Berg, J., Graf, R., & Gupta, A. (2022). De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Oncogene, 41(10), 1507–1517. https://doi.org/10.1038/s41388-022-02182-4

Abstract

Molecular events occurring in stepwise progression from pre-malignant lesions (pancreatic intraepithelial neoplasia; PanIN) to the development of pancreatic ductal adenocarcinoma (PDAC) are poorly understood. Thus, characterization of early PanIN lesions may reveal markers that can help in diagnosing PDAC at an early stage and allow understanding the pathology of the disease. We performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC (KC mice that harbor K-R